Hirofumi Makino Selected Research

Diabetic Nephropathies (Diabetic Nephropathy)

1/2022	Increase in BNP in Response to Endothelin-Receptor Antagonist Atrasentan Is Associated With Incident Heart Failure.
1/2022	Serum hemoglobin concentration and risk of renal function decline in early stages of diabetic kidney disease: a nationwide, biopsy-based cohort study.
12/2021	The Effect of Atrasentan on Kidney and Heart Failure Outcomes by Baseline Albuminuria and Kidney Function: A Post Hoc Analysis of the SONAR Randomized Trial.
2/2021	Randomized trial of an intensified, multifactorial intervention in patients with advanced-stage diabetic kidney disease: Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan).
1/2018	Rationale and protocol of the Study Of diabetic Nephropathy with AtRasentan (SONAR) trial: A clinical trial design novel to diabetic nephropathy.
1/2018	Estimated glomerular filtration rate decline and risk of end-stage renal disease in type 2 diabetes.
9/2017	Longitudinal Assessment of the Effect of Atrasentan on Thoracic Bioimpedance in Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial.
5/2017	Nodular lesions in diabetic nephropathy: Collagen staining and renal prognosis.
1/2017	The effects of atrasentan on urinary metabolites in patients with type 2 diabetes and nephropathy.
3/2016	Effects of blood pressure on renal and cardiovascular outcomes in Asian patients with type 2 diabetes and overt nephropathy: a post hoc analysis (ORIENT-blood pressure).

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Hirofumi Makino Research Topics

Disease

72	Diabetic Nephropathies (Diabetic Nephropathy) 01/2022 - 01/2002
36	Type 2 Diabetes Mellitus (MODY) 01/2022 - 07/2003
30	Albuminuria 12/2021 - 07/2004
27	Proteinuria 01/2019 - 04/2002
25	Vasculitis (Vasculitides) 01/2021 - 08/2008
24	Chronic Kidney Failure (Chronic Renal Failure) 01/2022 - 01/2002
23	Inflammation (Inflammations) 01/2021 - 10/2002
22	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 01/2021 - 06/2012
19	Hypertension (High Blood Pressure) 01/2020 - 10/2002
17	Hypertrophy 01/2015 - 10/2003
16	Body Weight (Weight, Body) 01/2022 - 02/2003
16	Glomerulonephritis 01/2021 - 11/2002
15	Fibrosis (Cirrhosis) 01/2016 - 02/2001
14	Chronic Renal Insufficiency 01/2022 - 01/2004
14	Rheumatoid Arthritis 11/2015 - 01/2004
12	Obesity 11/2015 - 04/2005
11	Microscopic Polyangiitis 01/2021 - 12/2009
11	Hyperglycemia 01/2016 - 07/2003
11	Insulin Resistance 01/2013 - 10/2002
10	Atherosclerosis 01/2013 - 01/2002
10	Nephrotic Syndrome (Syndrome, Nephrotic) 12/2012 - 01/2002
10	IGA Glomerulonephritis (IGA Nephropathy) 12/2012 - 04/2002
9	Edema (Dropsy) 12/2021 - 01/2002
8	Nephritis 01/2017 - 11/2002
8	Diabetes Mellitus 01/2016 - 04/2002
8	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2013 - 06/2005
7	Renal Insufficiency (Renal Failure) 01/2022 - 09/2006
7	Heart Failure 01/2022 - 05/2014
7	Granulomatosis with Polyangiitis (Wegener's Granulomatosis) 01/2021 - 12/2014
7	Neoplasms (Cancer) 01/2017 - 07/2003
6	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2021 - 10/2011
6	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 12/2005
6	Pituitary Neoplasms (Pituitary Adenoma) 02/2012 - 07/2003
5	Lupus Nephritis 01/2021 - 07/2003
5	Kidney Diseases (Kidney Disease) 10/2018 - 01/2012
5	Acute Kidney Injury (Acute Renal Failure) 12/2015 - 01/2002
5	Wounds and Injuries (Trauma) 01/2013 - 11/2005
5	Peripheral Arterial Disease 10/2012 - 11/2003
5	Acatalasia (Acatalasemia) 12/2011 - 06/2004
4	Stroke (Strokes) 01/2020 - 01/2010
4	Weight Gain 01/2018 - 02/2004
4	Infections 07/2017 - 09/2008
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2016 - 07/2003
4	Atrophy 01/2014 - 06/2004
4	Anemia 04/2011 - 03/2003

Drug/Important Bio-Agent (IBA)

32	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/2021 - 08/2008
30	CreatinineIBA 01/2022 - 08/2005
29	AlbuminsIBA 12/2021 - 10/2003
18	CytokinesIBA 01/2016 - 10/2002
16	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 01/2002
14	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 11/2003
14	Proteins (Proteins, Gene)FDA Link 01/2017 - 01/2005
13	AtrasentanIBA 01/2022 - 05/2014
13	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2004
13	Angiotensin IIIBA 12/2011 - 02/2001
11	Blood Glucose (Blood Sugar)IBA 01/2016 - 06/2003
10	Hemoglobins (Hemoglobin)IBA 01/2022 - 11/2008
10	GlucocorticoidsIBA 01/2020 - 04/2002
9	Peroxidase (Myeloperoxidase)IBA 10/2020 - 03/2012
9	Immunoglobulin A (IgA)IBA 01/2020 - 11/2003
9	Collagen Type IV (Type IV Collagen)IBA 01/2015 - 01/2002
9	Streptozocin (Streptozotocin)FDA Link 01/2014 - 02/2003
8	C-Reactive ProteinIBA 01/2021 - 06/2003
8	Angiotensin Receptor AntagonistsIBA 12/2015 - 07/2003
8	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 12/2015 - 01/2002
8	Messenger RNA (mRNA)IBA 11/2015 - 07/2003
8	Telmisartan (Micardis)FDA Link 01/2013 - 08/2004
8	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 08/2011 - 07/2003
7	Antigen-Antibody Complex (Immune Complex)IBA 01/2020 - 11/2003
7	Insulin (Novolin)FDA Link 01/2016 - 10/2002
7	Therapeutic UsesIBA 01/2015 - 11/2002
7	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 10/2012 - 02/2004
6	LigandsIBA 03/2013 - 01/2002
6	AdipokinesIBA 02/2013 - 07/2005
6	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2005 - 01/2004
5	Endothelin Receptor AntagonistsIBA 01/2022 - 05/2014
5	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2014 - 03/2011
5	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2014 - 06/2003
5	SteroidsIBA 12/2013 - 01/2002
5	CatalaseIBA 03/2012 - 06/2004
5	Angiogenesis InhibitorsIBA 04/2011 - 07/2004
4	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2021 - 06/2012
4	Prednisolone (Predate)FDA LinkGeneric 01/2021 - 08/2009
4	CholesterolIBA 01/2019 - 12/2011
4	Uric Acid (Urate)IBA 12/2018 - 02/2008
4	olmesartanIBA 03/2016 - 09/2006
4	ChemokinesIBA 03/2013 - 06/2005
4	Losartan (Cozaar)FDA LinkGeneric 03/2013 - 07/2006
4	Advanced Glycation End ProductsIBA 02/2013 - 10/2003
4	Adrenal Cortex Hormones (Corticosteroids)IBA 10/2012 - 01/2004
4	Pioglitazone (Actos)FDA Link 04/2012 - 07/2005
4	SaltsIBA 03/2012 - 03/2003
4	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2012 - 10/2003
4	AdiponectinIBA 01/2012 - 07/2005
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2010 - 11/2003

Therapy/Procedure

48	Therapeutics 11/2022 - 01/2002
10	Renal Dialysis (Hemodialysis) 04/2014 - 01/2002
9	Remission Induction 01/2021 - 06/2012
4	Kidney Transplantation 11/2019 - 09/2006
4	Peritoneal Dialysis 11/2012 - 01/2008